Scientists develop synthetic peptide that could inhibit toxic aggregates in Alzheimers disease – Business Standard

Researchers have developed synthetic peptides that could target and reduce toxic protein aggregates, which are supposed to cause disease, a new study finds.

The study was published in the Proceedings of the

is a caused by the aggregation of the toxic protein. Neurons in the human brain make a protein called Such proteins on their own, called monomers of amyloid beta, perform important tasks for neurons.

But in the brains of people with disease, monomers abandoned their jobs and get joined together. First, they form oligomers- small clusters of up to a dozen proteins- then longer strands and finally large deposits called plaques.

For years, scientists believed that plaques triggered the cognitive impairments characteristic of But newer research implicated the smaller aggregates of as the toxic elements of this

The research reported that the synthetic peptides- which are designed to fold into a structure known as an sheet- can block amyloid beta aggregation at the early and most toxic stage when oligomers form.

The team showed that the synthetic sheet’s blocking activity reduced amyloid beta-triggered toxicity in human neural cells grown in culture, and inhibited amyloid beta oligomers in two laboratory animal models for Alzheimer’s.

These findings add evidence to the growing consensus that amyloid beta oligomers- not plaques- are the toxic agents behind

The results also indicated that synthetic sheets could form the basis of therapeutics to clear toxic oligomers in people, according to

“This is about targeting a specific structure of amyloid beta formed by the toxic oligomers. What we have shown here is that we can design and build synthetic alpha sheets with complementary structures to inhibit aggregation and toxicity of amyloid beta while leaving the biologically active monomers intact,” said Daggett.

Using both novel and conventional spectroscopic techniques, Daggett’s team observed the individual stages of development of amyloid beta clusters, from monomers to six- and 12-protein oligomers all the way up to plaques, in human neural cell lines.

The researchers confirmed that the oligomer stages were most toxic to the neurons, which agrees with clinical reports of amyloid beta plaques in the brains of people who don’t have Alzheimer’s.

“Amyloid beta definitely plays a lead role in Alzheimer’s disease, but while historically attention has been on the plaques, more and more research instead indicates that amyloid beta oligomers are the toxic agents that disrupt neurons,” said Daggett.

The synthetic alpha sheet also protected laboratory animals from toxic oligomer damage. In brain tissue samples from mice, the team observed an up to 82 per cent drop in amyloid beta oligomer levels after treatment with a synthetic alpha sheet

Administering a synthetic alpha sheet to living mice triggered a 40 per cent drop in amyloid beta oligomer levels after 24 hours.

In the common laboratory worm Caenorhabditis elegans (C. elegans), another model for Alzheimer’s disease, treatment with synthetic alpha sheets delayed the onset of

For the current study, the researchers also created a novel laboratory assay that uses a synthetic alpha sheet to measure levels of amyloid beta oligomers. They believe this assay could form the basis of a clinical test to detect toxic oligomers in people before the onset of Alzheimer’s symptoms.

“What we are really after are potential therapeutics against amyloid beta and diagnostic measures to detect toxic oligomers in people. Those are the next steps,” said Daggett.

(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)

Indian destroyer warship in Qingdao, to help Chinese navy plan mega parade – Hindustan Times

Battleships from India, Singapore and Australia were among several foreign navies to arrive in the eastern port city of Qingdao on Sunday to take part in a maritime parade to mark the 70th anniversary of the People’s Liberation Army Navy (PLAN).

On Tuesday, China is expected to display new warships including nuclear submarines, destroyers, warplanes and the country’s first aircraft carrier at the parade in the Yellow sea off the Qingdao coast.

More than a dozen foreign navies will take part in it.

As reported by Hindustan Times on April 7, conspicuous by its absence will be the Pakistan navy, which hasn’t dispatched any warship for the event that includes an international fleet review to be inspected by President Xi Jinping on April 23.

Given the strong ties between China and Pakistan – who call each other “iron brothers” – it was expected that Islamabad would also dispatch its frontline warships for the big military event.

Also read: Indian foreign secretary VijayGokhale to raise Masood Azhar’s listing during China visit

Neither Islamabad nor Beijing has explained the reason for not taking part in it; it is possibly because of the Indian navy’s heightened deployment in the Arabian sea region following the air skirmish with Pakistan in February.

Incidentally, China is building the first of four ‘most advanced’ naval frigates for Pakistan as part of a major bilateral arms deal, the state-controlled China Daily reported in January.

The vessels, a version of China’s guided missile frigates, will be equipped with state of the art sensors and weapons system

For the Indian navy and its personnel, it will be a rare chance to interact with Chinese counterparts during the event.

Besides INS Kolkata commanded by Captain Aditya Hara, India has also sent supply ship, INS Shakti, commanded by Captain Sriram Amur. “We bring to you one of the best ships that we have made. It is the pride of the nation and the navy, and we are very happy to be here,” Captain Aditya Hara told reporters on the dockside after disembarking from the ship in Qingdao, reported Reuters from Qingdao.

“We headed on a direct route and we are very happy that we were facilitated by the PLA Navy and they ensured that we had a safe passage to Qingdao,” Hara said, when asked if they had sailed via the Taiwan Strait, a waterway that divides China and self-ruled Taiwan.

“Participation by the Indian Navy in the PLA Navy IFR is part of the efforts towards deepening the military-to-military relations between India and China, which is in keeping with the strategic guidance provided by the leaders of both countries,” the Indian embassy said in a statement.

“It is anticipated that the PLA Navy IFR will further this ongoing process of enhancing mutual trust and understanding. A range of professional, cultural and sports exchanges are planned. Professionally, the ships’ crews will not only participate in planning and executing the parade at sea, but will also meet separately for experience sharing,” the statement added.

More than 60 countries will send delegations to join multinational naval events marking the anniversary and over 30 countries of them will send major navy leaders, PLAN’s senior navy officer Qiu Yanpeng told a press conference at Qingdao on Saturday.

China’s first aircraft carrier, the Liaoning, and latest nuclear submarines, destroyers and fighter jets will join the parade, Qiu Yanpeng, deputy commander of the PLA Navy, told a press conference in Qingdao.

“Some vessels will make their debut for the first time,” Qiu said.

Altogether 32 Chinese vessels and 39 warplanes will take part in the event, Qiu added.

First Published:
Apr 21, 2019 15:37 IST

Oral immunotherapy safe for children allergic to peanuts – Hindustan Times

A recent study has claimed that oral immunotherapy given as routine treatment is safe for preschoolers allergic to peanuts. Oral immunotherapy (OIT) is a treatment protocol in which a patient consumes small amounts of the allergenic food.

“Although there have been many clinical trials of peanut oral immunotherapy in older children and one trial in preschoolers, there has been a lack of real-world data due to safety concerns of offering this treatment to preschoolers outside of a research setting,” said Lianne Soller, the lead author of the study which was published in Journal of Allergy and Clinical Immunology.

Children were seen by a pediatric allergist every two weeks, where they were fed a peanut dose that gradually increases in every visit. Parents also gave children the same daily dose at home, between clinic visits, until they reached a maintenance dose of 300 mg of peanut protein.

Symptoms and treatment of allergic reactions at clinic visits and at home, including epinephrine use, were recorded in the patient’s medical chart.

Parents were given instructions on how to manage at-home allergic reactions, when to administer epinephrine, and when to hold off on an OIT dose, such as during severe cold or flu.

“The goal of our project was to confirm the safety of preschool peanut OIT in a much larger sample of patients in the real world,” said Dr. Edmond Chan, senior author.

The researchers found that 243 children (90%) reached the maintenance stage successfully, while 27 children, or 10 per cent, dropped out.

It took an average duration of 22 weeks of oral immunotherapy for patients to reach the maintenance stage.

“Many allergists do not believe OIT should be offered outside of research settings, and have not routinely offered it as a therapy for peanut allergy in their clinics due to safety concerns. We hope that our data demonstrates that the treatment is safe in preschoolers, and could be offered to families of preschool children with peanut allergy who ask for it. There appears to be a big difference in outcomes in preschoolers compared to older children,” he said.

The group now hopes to investigate the long-term safety and efficacy of peanut OIT desensitisation and sustained unresponsiveness for patients who choose to stop daily peanut OIT.

“He hopes the findings provide guidance to health-care practitioners treating preschool children in their clinics,” said Chan.

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First Published:
Apr 21, 2019 15:17 IST

Elections 2019: Rahul To Be Prime Minister If Congress Gets Maximum Seats: Anand Sharma – NDTV News

Anand Sharma alleged that PM and the BJP were resorting to emotional pleas in their campaign.

Panaji: 

Congress leader and Rajya Sabha MP Anand Sharma on Sunday said Rahul Gandhi will be the next prime minister of the country if the Congress gets the highest number of seats in the April-May Lok Sabha polls.

Addressing a press conference here, Mr Sharma said Prime Minister Narendra Modi and his NDA government will face the same fate as the Atal Bihari Vajpayee government in 2004 when the BJP lost despite a robust ‘India Shining’ campaign.

“Leaders will decide who will be the next PM. It all depends on which party leads. If it is the Congress, then the next PM will be our chief Rahul Gandhi,” he said.

“There are pre-poll alliances and also there is post-poll coalition. It will all depend on the results,” he added.

Predicting the BJP’s performance in the ongoing general elections, Mr Sharma said, “This question was put before us in 2004 when a far better PM, in the form of Atal Bihari Vajpayee, was there but what happened? India Shining lost. The same is going to happen now.”

“I am not an astrologer but one thing I can tell you is that PM Modi will not become PM and the BJP will be defeated. Congress will get a high number of seats,” he claimed. “The question today is what is the narrative? Is the PM promising anything to the people? Is the PM not supposed to give an account of what he has done in the last five years?” Mr Sharma questioned. Mr Sharma said the PM should apologise for not fulfilling the promises made during the 2014 Lok Sabha campaign.

He also alleged that PM and the BJP were resorting to emotional pleas in their campaign. “They are playing with the emotions of people. It is a matter of shame. For the first time in the history of this country, the PM is using the armed forces for a partisan political agenda. He should be condemned for it,” he alleged. “The Indian Army does not belong to the Narendra Modi government. It belongs to the people and nation. They have insulted the martyrdom and sacrifice of our soldiers,” he added.

He said the BJP need not give lessons to the Congress on fighting terrorism as the country’s oldest party had lost two prime ministers – Indira Gandhi and Rajiv Gandhi- in this fight.

Get the latest election news, live updates and election schedule for Lok Sabha Elections 2019 on ndtv.com/elections. Like us on Facebook or follow us on Twitter and Instagram for updates from each of the 543 parliamentary seats for the 2019 Indian general elections.

‘Preserve neutrality, fairness’: Women lawyers say CJI should not hold office until inquiry is over – Scroll.in

The Women in Criminal Law Association on Saturday demanded an inquiry “at the earliest” into the sexual harassment allegation against Chief Justice of India Ranjan Gogoi and said he should not hold office during the process. The group distanced itself from the statement by Bar Council of India, which had called the allegation “false and cooked up”.

A 35-year-old woman who used to work as a junior court assistant at the Supreme Court wrote to 22 judges of the court on Friday, alleging that Gogoi had made sexual advances on her at his residence office in October 2018. The woman said that after she rebuffed the chief justice, she was moved out of his residence office, where she had been posted in August 2018. Two months later, she was dismissed from service. One of the three grounds for dismissal, as detailed in the inquiry report, was that she had taken casual leave for one day without approval.

The Supreme Court constituted a special bench on the “independence of the judiciary”, to sit immediately to address the matter on Saturday. Gogoi, who has denied the allegation, claimed that the judiciary was under serious threat but that the matter would be considered by senior judges of the court. The judges said an appropriate bench would hear the charges against Gogoi.

In its statement, the Women in Criminal Law Association said: “Even before the allegations properly came to light, the stated purpose of the sitting sought to change the conversation.”

Over 700 people have endorsed the statement so far. “We believe that the complaint should be treated as per procedure and principles of fairness and justice, including the fundamental right to equality before law,” the statement said.

It further said: “The said procedure must be in accordance with the in-house procedure applicable to the judges of the Supreme Court and the letter and spirit of the POSH Act [Sexual Harassment of Women at Workplace (Prevention, Prohibition and Redressal) Act, 2013], the Supreme Court Sexual Harassment Regulations, 2013 and service rules if applicable.”

The complainant should have the utmost opportunity to present her case, as must the respondent to present his defence, the statement said. “It is our opinion that, due to the immense disparity in power and position, the Hon’ble Chief Justice of India cannot continue to hold office during the inquiry,” it added.

The group said: “Needless to say, the inquiry must take place at the earliest and with unimpeachable and transparent process in order to preserve the dignity of our Apex Court. To this end, the Complainant must be protected from all coercive action and online harassment during the pendency of the inquiry.”

The statement also said that “to preserve neutrality and fairness”, such an inquiry should not involve the judges who were part of the sitting on Saturday, the court’s Secretary General, and Attorney General and Solicitor General.

“Furthermore, the record of proceedings or ‘order’ of the day (which does not reflect the presence or submissions of the Chief Justice) ought to be corrected to reflect the true constitution and purpose of the bench,” the statement said.

TCS modernises 1.5 lakh post offices under multi-year deal with India Post – Economic Times

NEW DELHI: India’s largest IT services company
Tata Consultancy Services (
TCS) said it has deployed an integrated solution for India Post that has helped modernise a network of more than 1.5 lakh
post offices in the country.

In 2013, the Mumbai-based company had announced receiving an over Rs 1,100- crore multi-year contract from the Department of Posts (DoP) for an end-to-end IT modernisation programme.

The partnership was aimed at equipping India Post with modern technologies and systems to enable it to offer more services to the customers in an effective manner.

“At the heart of this transformation is the Core System Integration (CSI) program designed and implemented by TCS. This involved deploying an integrated ERP solution that caters to mail operations, finance and accounting, and HR functions, and connects its vast network of more than 1.5 lakh post offices, making this the largest distributed e-postal network in the world,” TCS said in a statement.

The integrated solution supports requirements of over five lakh employees, services over 40,000 concurrent users, and processes over three million postal transactions a day, making this one of the largest SAP implementations globally, it added.

On the front-end, TCS said, it has implemented its Point of Sale (PoS) solution across 24,000 post offices with over 80,000 PoS terminals and has also built a web portal with consignment tracking capabilities, and set up a multi-lingual call centre for customer support.

“An important objective of the transformation is to use the department’s nation-wide reach to drive financial inclusion and accessibility of citizen services in remote areas.

“This is being accomplished through over 1.3 lakh DARPAN 1 hand-held devices that Gramin Dak Sevaks use to provide postal, banking, insurance, and cash management services in remote villages, even those without network connectivity,” TCS said.

TCS Business Group Head (Public Services) Debashis Ghosh said postal services across the world are reinventing themselves to stay relevant to a new generation in the digital era.

“We are proud to have partnered with the Department of Posts in this pioneering, mission mode initiative to build a world class, future-ready digital platform that the nation can be proud of. With this, the department can offer smart postal services, enriched customer experiences, and innovative value-added services to the citizens of India,” he added.

Huawei P30 Pro survives bend, scratch test; display can handle intense burns – Firstpost

If smartphone durability matters to you then it’s quite likely that you’ve heard about Zach Nelson aka JerryRigEverything.

The latest new flagship to go under the scanner and brave through Nelson’s standardised set of durability tests is the Huawei P30 Pro.

Beginning with the scratch test, the tempered glass on the Huawei P30 Pro is seen getting scratches at Moh level 6 or 7, which is the norm in flagship grade phones. The Huawei P30 Pro is made of tempered glass and stands tall in the bend test as well, barely flexing even with a lot of pressure. To recall, the Huawei P20 Pro didn’t do so well in the bend test last year, the display cracking under pressure.

Huawei P30 Pro survives bend, scratch test; display can handle intense burns

The Huawei P30 Pro. Image Tech2/ Prannoy Palav

The frame of the Huawei P30 Pro is made of metal and they do suffer cracks fairly easily. The phone is seen to sport an Infrared LED indicator that will help in controlling TVs. The back is also quite resistant to scratches, and even the protection over the camera lenses at the back is unaffected by heavy scratching with a blade.

The phone’s display is also put to fire with a lighter, and the die out only after 22 seconds of being under a naked flame. The Huawei P30 Pro’s display briefly stops working, but a reboot gets it back on track right away.

The display over the in-display fingerprint scanner is also heavily scratched to see if it works after the damage. The sensor is seen to work well even after the scratches, lending more weight to the phone’s durability.

The video is definitely worth a watch, and we can’t wait to see the insides of the P30 Pro in the teardown video that will presumably follow in the next few days.

(Also read: Huawei P30 Pro Review: Complete package with a giant leap for smartphone cameras)

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Ola in talks with luxury carmakers Audi, Mercedes for self-drive subscription services: Report – Moneycontrol.com

Ride-hailing platform Ola is in discussions with luxury carmakers, including Audi, Mercedes and BMW, to launch a subscription-based service under its self-drive offering, according to sources.

Ola has been running a small-scale pilot of the self-drive service in Bengaluru currently, and is expected to launch the offering in the next few weeks through Ola Fleet Technologies.

The company is also believed to have earmarked an investment of up to $500 million (including debt) for the self-drive service.

According to sources privy to the development, the company is in talks with carmakers like Audi, Mercedes and BMW to bring to India a model where users can get access to luxury cars by paying a subscription fee.

Email queries sent to Ola, Audi, Mercedes and BMW did not elicit any response.

One of the persons said the format is available in developed markets like the US, but given the high cost of luxury vehicles in India, a direct-to-customer model may not be not feasible in the country.

The person added that Ola sees a lot of potential in bringing this model to India given its scale of operations across multiple categories and cities.

Ola already allows customers to book rides in luxury cars through its ‘Lux’ offering. In October 2016, the Bengaluru-based company had partnered with BMW for expanding the category.

The company, which competes with the US-based Uber in India and international markets like Australia, has been aggressively ramping up its rides business as well as food delivery operations (through Foodpanda).

It had recently announced that Hyundai and Kia are investing $300 million in the company.

Ola, which counts names like SoftBank Group and China’s Tencent Holdings among its investors, had received Rs 650 crore funding from Flipkart co-founder Sachin Bansal in February this year.

Ola’s electric mobility arm Ola Electric Mobility has also raised Rs 400 crore from Tiger Global, Matrix India and others.

Jacqueline Fernandez to Vivek Oberoi: Bollywood celebs condemn Sri Lanka serial blasts – India Today

After six serial blasts rocked Sri Lanka on Sunday morning, killing over 138 people and injuring more than 300, many Bollywood celebs took to Twitter to condemn the attacks and send their condolences to people who lost their lives.

Jacqueline Fernandez, who is from Sri Lanka, took to Twitter to express grief. She wrote, “Extremely sad at the news of bombings in Sri Lanka. It’s unfortunate that one is not able to see that violence is like a chain reaction. This has to stop!”

Anushka Sharma tweeted. She said, “Our hearts go out to everyone affected by this tragic act of violence in Sri Lanka. We are praying with you in this painful moment of sorrow, grief and shock.”

Parineeti Chopra said, “Could never have thought a quiet country like #Srilanka could be attacked like this. What is the world coming to? Thinking of all the families affected. All my love and prayers always …”

Arjun Kapoor called the atacks monstrous. He said, “Really disturbed to hear about the monstrous attack in #SriLanka on such an auspicious day. My thoughts and prayers to the families of the affected.”

Director Madhur Bhandarkar called the attacks shameful. He tweeted saying, “It’s a extremely shameful act of terrorism to attack innocent civilians. My heartfelt condolences to the one who lost their lives and praying for the safety of everyone affected in #SriLanka. Stay Strong!”

Vivek Oberoi tweeted saying, “More Deeply saddened and shocked by the tragic and terrible attacks in #SriLanka. An act of cowardice on a day of prayer, shame on these terrorists. My sincere prayers with the victims and their families. We are all with you #SriLanka. Please stay safe.”

Huma Qureshi also tweeted. She said, “What a sad day !! To attack families and children going to church on #EasterSunday !!! This is terrible … what is happening to our world??? #SriLanka.”

Rang De Basanti fame Siddharth tweeted saying, “What a tragic Easter Sunday. The devil knows no mercy. To attack families and children when they are most vulnerable… This is beyond comprehension. #PrayForSriLanka.”

Director Kunal Kohli tweeted saying, “Heart goes out to the people of #srilanka. Another cowardly terrorist attack. #Wearewithyousrilanka 80 Injured In Six Blasts In Sri Lanka Churches And Hotels On Easter.”

The blasts took place at 8.45 am (local time) as the Easter Sunday masses were in progress.The Sri Lankan army has deployed 200 troops to ensure security.

Also Read | 138 killed, over 400 hurt in Sri Lanka serial blasts targeting churches, hotels on Easter

Also Read | Politicians, actors, world leaders condemn Sri Lanka serial blasts as toll continues to rise

Also Read | Gunmen kill 13 at Veracruz bar in one of worst Mexican slayings this year

Also Watch | 49 killed, over 200 hurt in multiple blasts in Sri Lanka

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Happy Easter Sunday 2019: Wishes Images, Messages, Whatsapp Status, Pictures, Quotes, GIF Pics, Photos – The Indian Express

Happy Easter
Happy Easter Sunday 2019 Wishes Images: Have a blessed Easter. (Source: Designed by Gargi Singh)

Happy Easter Sunday 2019 Wishes Images, Messages, Photos, and Status: As one of the prominent days for Christians, Easter is celebrated with much fanfare. Marking the resurrection of Jesus from the dead on the day of Good Friday, Easter symbolises new beginnings. It is widely believed that when Jesus Christ’s disciples visited his grave on the third day following Good Friday, the grave was empty and the stone was rolled away.

The popular proclamation on the day became “He is Risen”. This joyful proclamation stands till today and his resurrection is celebrated as the triumph of the Lord and his son. It is widely considered to be God’s plan to save people from sins and wrongdoings.

Easter is often associated with Easter eggs as a symbol of new life or spring in which the outside seems dead but the inside is full of life. On the occasion of Easter, send your friends and family greetings of the festival. Here are some wishes you can share with them:

Happy Easter 2019
Happy Easter Sunday 2019 Wishes Images: Sing hallelujah! (Source: Designed by Gargi Singh)

Happy Easter!
Rejoice and praise Jesus!!!

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Happy Easter 2019
Happy Easter Sunday 2019 Wishes Images: Christ has risen. (Source: Designed by Gargi Singh)

Sing hallelujah!!!
Happy Easter!

Choose to follow The Lord
May you receive “a new birth of everlasting happiness”
Happy Easter!

Happy Easter 2019
Happy Easter Sunday 2019 Wishes Images: Easter is celebrated with much fanfare. (Source: Designed by Gargi Singh)

It’s not just about the Easter egg or bunnies
It’s the hope that this season enfolds in everyone’s homes.

Happy Easter 2019
Happy Easter Sunday 2019 Wishes Images: Easter is one of the prominent days for Christians. (Source: Designed by Gargi Singh)

Happy Easter 2019
Happy Easter Sunday 2019 Wishes Images: Celebrated as Jesus’ resurrection from the dead. (Source: Designed by Gargi Singh)

Heartiest greeting to you and your family on this auspicious occasion
Happy Easter!